Origin and Features of the K562 Cell line The K562 cell line was derived from the bone marrow sample of a patient with chronic myeloid leukemia (CML). It was first isolated and characterized by Peter Nowell and David Hungerford in the early 1960s. While studying bone marrow samples from leukemia patients, scientists identified a unique […]
Origin and Features of the Jurkat T Cell The Jurkat T Cell, Clone E6-1 cell is a pseudodiploid human cell line derived from acute T cell leukemia. It was established in 1984 by Dr. Schneider from a peripheral blood sample of a 14-year-old male patient. The E6-1 cell is a clonal derivative of the Jurkat-FHCRC […]
Origin and Features of the MIA-PACA-2 The MIA PaCa-2 cell line is an epithelial cell line isolated and established from the tumor tissue of a 65-year-old Caucasian male with pancreatic cancer. The establishment of the MIA PaCa-2 cell line began in 1975 by A. Yunis et al. and was formally established in 1977. MIA PaCa-2 […]
Origin and Features of the MKN-74 The MKN74 cell line is a human gastric cancer cell line originally isolated by the Japanese National Cancer Center Research Institute from a liver metastasis of a 37-year-old male patient with moderately differentiated tubular adenocarcinoma. MKN74 cells exhibit morphological features associated with intestinal differentiation, including cell polarity and microvilli […]
Origin and Features of the MCF-7 MCF-7 cells are epithelial cells isolated from the breast tissue of a 69-year-old Caucasian female with metastatic adenocarcinoma. These cells express the genes encoding insulin-like growth factor binding protein (IGFBP)-2, IGFBP-4, and IGFBP-5, as well as estrogen receptors. MCF-7 cells can be used for 3D cell culture, immuno-oncology, and […]
Origin and Features of the A549 The A549 cell line was initially isolated in 1972 from the lung tissue of a 58-year-old Caucasian male patient with lung adenocarcinoma[1]. These cells are cancerous derivatives of human alveolar basal epithelial cells and possess unique characteristics that make them a common model for studying lung cancer and other […]
